Pengaruh Rasio HA/TCP terhadap Karakteristik Komposit BCP-Gelatin-CMC sebagai Bahan Injectable Bone Substitute
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Abstract
Penambahan bahan semen tulang kedalam rongga tulang dapat menjadi salah satu alternatif untuk mencegah kerusakan tulang akibat osteoporosis. Kelemahan utama dari bahan implant ortopedik berbasis hydroksiapatit sinter adalah bahan dalam bentuk solid dimana dalam aplikasi pembedahan, sulit untuk mengisi rongga tulang dengan ukuran tertentu. Alternatif yang nyaman untuk bahan pengisi tulang suspensi adalah dengan menggunakan bahan Injectable bone substitute. Dalam studi ini dipelajari komposisi material Injectable Bone substitute dengan matrik berupa polimer CMC-gelatin dan HA/TCP sebagai filler. Dilakukan variasi rasio Hidroksiapatit (HA) / tri-calcium phosphate (TCP) (70:30; 50:50; 40:60)  untuk  mempelajari pengaruhnya terhadap sifat-sifat fisik dan mekanik campuran. Hasil uji FTIR menunjukkan gugus fungsi fosfat (PO43-) gugus fungsi karboksil dan gugus fungsi NH2 yang merujuk kepada bahan penyusunnya. Peningkatan porositas karena perubahan morfologi dikonfirmasi oleh gambar mikroskop polaritas. Hasil uji tekan menunjukkan berkurangnya  nilai kuat tekan dengan bertambahnya konsentrasi TCP dalam campuran. Semua kelompok uji menunjukkan kemiripan struktural dengan tulang cancellous dalam sifat porositas dan kekuatan mekanik.
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References
Bohner M, Gasser B, Baroud G, Heini P. 2003. "Theoretical and experimental model to describe the injection of a polymethylmethacrylate ce-ment into a porous structure". Biomaterials;24:
–2730.
Samartzis D, Shen FH, Goldberg EJ,An HS. 2005. "Is autograft the gold standard in achiev-ing radiographic fusion in one-level anterior cer-vical discectmy and fusion with rigid anterior plate fixation?" Spine (Phila Pa 1976);30:1756–61.
Greenwald AS,Boden SD,Goldberg VM, et al. 2001."Bone-graft substitutes:facts,fictions, and applications". J Bone Joint Surg Am;83-A(Suppl. 2 (Pt 2)):98–103.
Wimmer C, Krismer M, Gluch H, Ogon M, Stockl B. 1999. "Autogenic versus allogenic bone grafts in anterior lumbar interbody fusion". Clin Or-thop;360:122–126
Merkx MAW, Maltha JC, Freihofer HP, Kuijpers-Jagtman AM. 1999. "Incorporation of three types of bone block implants in the facial skele-ton". Biomaterials;20:639–645
Sarkar MR, Wachter N, Patka P, Kinzl L. 2000. "First histological observations on the incorpora-tion of a novel calcium phosphate bone substi-tute material in human cancellous bone". J Bio-med Mater Res;58:329–334
Larsson S, Hannink G. 2011."Injectable Bone substitute : current product, their characteristics and indications, and new development". Inju-ry;42 suppl 2;S30-4
Campana V, Milano G, Pagano E, Barba M, Cicione C, Salonna G, Lattanzi W, Logroscino G. 2014 Oct. " Bone substitutes in orthopaedic sur-gery: from basic science to clinical practice ". J Mater Sci Mater Med.; 25(10):2445-61
Ghosh SK, Nandi SK, Kundu B, Datta S, De DK, Roy SK, Basu D J. 2008 Jul ." In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution com-bustion method and comparison with bioglass scaffolds ".Biomed Mater Res B Appl Biomater.; 86(1):217-27
Spivak JM, Hasharoni .2001 Oct." A Use of hy-droxyapatite in spine surgery".Eur Spine J.; 10 Suppl 2:S197-204
Xie J, Baumann MJ, Mc Cabe LR. 2004 Oct. "Osteoblasts respond to hydroxyapatite surfaces with immediate changes in gene expression". J Biomed Mater Res A. 1; 71(1):108-17
Saikia KC, Bhattacharya TD, Bhuyan SK, Ta-lukdar DJ, Saikia SP, Jitesh P .2008 Apr."Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects".Indian J Orthop.; 42(2):169-72
Lee KS, Chang JS, Kim JH, et al. 2009."The role of osteoclast in resorption of hydroxyapatite and β-tricalcium phosphate coating layer". Key Eng Mater ; 396–398: 81–84
Sarikaya Burcu, Aydin HM. 2015. "Colla-gen/Beta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing". BioMed Research International Volume. Article ID 576532
Ko-Ning Ho, Eisner Salamanca, Kuo-Chi Chang et.al. 2016." A Novel HA/β-TCP-Collagen Com-posite Enhanced New Bone Formation for Den-tal Extraction Socket Preservation in Beagle Dogs". Materials, 9, 191; doi:10.3390/ma9030191
Faour O, Dimitriou R, Cousins CA, Giannoudis PV. 2011 Sep. "The use of bone graft substitutes in large cancellous voids: any specific needs?". Injury 42 Suppl 2:S87-90
Aniek S.B., Muhamad Z., Ferdiansyah., dan Fa-thia R. 2010. "Efektivitas Matriks
Komposit Bovine Hydroxyapatite – Gelatin Se-bagai Sistem Penghantaran Gentamisin Dan Re-generasi Tulang Pada Bone Defect", Tesis, Pro-gram Pascasarjana Ilmu Kedokteran, Universi-tas Airlangga, Surabaya.
Moore, William R., Graves, Stephen E., Bain, Gregory I. 2001. Synthetic Bone Graft Substi-tutes, ANZ J. Surg., 71, 354–361
An YH. 2000."Mechanical properties of bone". In: An YH, Draughn RA, editors. Mechanical testing of bone and the bone-implant interface. Boca Raton: CRC Press;. p. 41
Daculsi G, LeGeros RZ, Heughebaert M, Barbieux I. 1990."Formation of carbonate– apa-tite crystals after implantation of calcium phos-phate ceramics". Calcif Tissue Int;46:20–7
Gauthier O, Bouler JM, Weiss P, et al. 1999. "Ki-netic study of bone ingrowth and ceramic resorp-tion associated with the implantation of different injectable calciumphosphate bone substitutes". J Biomed Mater Res;47:28–35
H. Yuan, H. Fernandes, P. Habibovic, J. D. Boer, A. M. C. Barradas, an A.D. Ruiter.2010. “Oste-oinductive ceramics as a synthetic alternative to autologous bone grafting,†Image (Rochester, N.Y.), vol. 107, no. 31:10-1