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Observation of imunomodulation properties of methanol extract derive (hexane,
ethyl acetate, methanol/water) of Curcuma mangga (temu mangga) and KaempferiaÂ angustifolia (kunci menir) had been carried out by in vitro assay. It was done byÂ determining the phagocytised activity and capacity of macrophage cells of mice (MusÂ musculus) peritonium inducted with Staphyllococcus epidermidis. The result showed thatÂ each fraction had different phagocytised activity and capacity. Almost all of the fractionsÂ tested improved the activity (50â€“96 %) and capacity macrophage cells phagocytisedÂ compared to negative control (52 dan 502) and positive control (97 dan 1076). TheÂ positive control was 1000 ug Stimuno (Phyllanthus niruri extract), while the negativeÂ control was aquadest. The ethyl acetate fraction of Z. cassumunar (bangle) had highest
phagocytised activity and capacity followed by C. mangga (temu mangga) and K.Â Angustifolia (kunci menir). It can be concluded that there were significant differencesÂ of phagocytised activity and capacity among fraction tested.
Keywords : Zingiberaceae, Curcuma mangga, Kaempferia rotunda, Zingiber
cassumunar, immunomodulator, phagocytised, macrophage cells.
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